CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13229
Family Name Histamine H3 receptor and Sodium-dependent serotonin transporter ligand AGN-PC-00R9BM family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00421143 Functional Category Bioactive
Superfamily Histamine H3 receptor and Sodium-dependent serotonin transporter Binder Superfamily 3
Class Class 280

Cousin Family NamesSeedsMembers
Squalene monooxygenase Inhibitor Tolnaftate Family 1 4
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Renin Inhibitor Ro-66-1168 Family 10 30
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
Sodium-dependent serotonin transporter inhibitor SureCN3890472... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 9
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Estrogen receptor and Estrogen receptor beta ligand SureCN6716... 2 0
Histamine H3 receptor ligand SureCN3057839 family 1 0
Amyloid beta A4 protein inhibitor 2-(fluoranylmethyl)-3-[4-[(E... 1 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 7
Estrogen receptor beta and Estrogen receptor ligand (E)-3-[4-(... 1 0
Protein-S-isoprenylcysteine O-methyltransferase inhibitor N-[2... 1 2
Amyloid beta A4 protein inhibitor 2-[(4-bromophenyl)methyl]-3-... 1 0
NP (e)-4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)vinyl)-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421143 CHEMBL238951 Bioactive AGN-PC-00R9BM
CFAMM00421142 CHEMBL392892 Bioactive AGN-PC-00R7WI

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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