CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13233
Family Name Prostaglandin D2 receptor 2 ligand 2-[3-[(E)-2-cyano-3-(N-methylanilino)-3-oxoprop-1-enyl]-4-fluoroindol-1-yl]acetic acid family
No. of Seeds 9 No. of Other Members 9
Family Centroid CFAMM00421205 Functional Category Bioactive with Natural Product
Superfamily DNA polymerase beta and Retinal dehydrogenase 1 Binder Superfamily 6
Class Class 926

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
Thromboxane A2 receptor Ligand Ramatroban Family 13 49
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Substance-P receptor Ligand TAK-637 Family 18 63
Histone deacetylase 1 Inhibitor Resminostat Family 2 5
Setipiprant family 5 118
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Adenosine receptor A1 and Adenosine receptor A2a Ligand FK-838... 4 19
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 3 11
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Aldose reductase Inhibitor 3-(3-benzoyl-1h-pyrrol-1-yl)propano... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Neuropeptide Y receptor type 5 ligand 2-(6-chloroindol-1-yl)-N... 4 23
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Prostaglandin D2 receptor 2 ligand 2-[5-fluoro-2-methyl-3-[(4-... 3 5
Integrase inhibitor (Z)-4-[5-chloro-1-[(4-fluorophenyl)methyl]... 3 9
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 2 9
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Prostaglandin D2 receptor 2 and Prostaglandin G/H synthase 1 l... 3 17
Prostaglandin D2 receptor 2 ligand SureCN317401 family 3 8
Prostaglandin D2 receptor 2 ligand 2-[(3R)-3-(3,3-diphenylprop... 1 0
Prostaglandin D2 receptor 2 ligand 2-[3-[(3-chlorophenyl)-meth... 1 0
Prostaglandin D2 receptor 2 and Cytochrome P450 2C19 ligand 2-... 6 13
Prostaglandin D2 receptor 2 ligand 2-[5-fluoro-3-[[1-[[4-(2-hy... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
NADPH oxidase 4 inhibitor AGN-PC-09M5SP family 1 1
Putative NP ZINC00969838 Family 6 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421213 CHEMBL2391518 Bioactive 2-[3-[(E)-2-cyano-3-(3,4-dihydro-2H-quinolin-1-yl)-3-oxoprop-1-enyl]indol-1-yl]acetic acid
CFAMM00421204 CHEMBL2391525 Bioactive 2-[5-chloro-3-[(E)-2-cyano-3-(N-methylanilino)-3-oxoprop-1-enyl]indol-1-yl]acetic acid
CFAMM00421212 CHEMBL2391519 Bioactive 2-[3-[(E)-2-cyano-3-(6,11-dihydrobenzo[c][1]benzazepin-5-yl)-3-oxoprop-1-enyl]indol-1-yl]acetic acid
CFAMM00421203 CHEMBL2391524 Bioactive 2-[4-chloro-3-[(E)-2-cyano-3-(N-methylanilino)-3-oxoprop-1-enyl]indol-1-yl]acetic acid
CFAMM00421201 CHEMBL2390962 Bioactive 2-[3-[(E)-2-cyano-3-(N-methylanilino)-3-oxoprop-1-enyl]-4-methylindol-1-yl]acetic acid
CFAMM00421207 CHEMBL2391528 Bioactive 2-[3-[(E)-2-cyano-3-(N-methylanilino)-3-oxoprop-1-enyl]-5-methylindol-1-yl]acetic acid
CFAMM00421206 CHEMBL2391521 Bioactive 2-[3-[(E)-2-cyano-3-(N-methylanilino)-3-oxoprop-1-enyl]-5-fluoroindol-1-yl]acetic acid
CFAMM00421214 CHEMBL2391516 Bioactive 2-[3-[(E)-2-cyano-3-oxo-3-[N-(2-phenylethyl)anilino]prop-1-enyl]indol-1-yl]acetic acid
CFAMM00421205 CHEMBL2391520 Bioactive 2-[3-[(E)-2-cyano-3-(N-methylanilino)-3-oxoprop-1-enyl]-4-fluoroindol-1-yl]acetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26830 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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