CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13237
Family Name Sigma non-opioid intracellular receptor 1 ligand 1-benzyl-4-[(3-iodophenyl)methylsulfonyl]piperazine family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00421246 Functional Category Bioactive
Superfamily Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor Binder Superfamily 5
Class Class 4371

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
5-hydroxytryptamine receptor 7 and D(2) dopamine receptor Liga... 3 29
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 12 20
Potassium voltage-gated channel subfamily H member 2 Ligand 4-... 4 26
Melanin-concentrating hormone receptor 1 Ligand N,n-bis(tosylm... 2 1
Oxytocin receptor and Vasopressin V1a receptor Ligand 1'-tosyl... 1 7
Squalene synthase Inhibitor Zwitterionic Sulfobetaine Derivati... 2 20
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 34
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 11
Histamine H3 receptor ligand 2-[4-[4-[2-[(2R)-2-methylpyrrolid... 4 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 10
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Sigma non-opioid intracellular receptor 1 ligand 4-benzyl-1-[(... 1 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 4 0
C-C chemokine receptor type 5 ligand AC1L9YN4 family 2 33
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 2


External ID

Functional Category

Molecule Name

CFAMM00421246 CHEMBL2391061 Bioactive 1-benzyl-4-[(3-iodophenyl)methylsulfonyl]piperazine
CFAMM00421252 CHEMBL2391071 Bioactive 4-benzyl-1-[(3-iodophenyl)methylsulfonyl]piperidine
CFAMM00421249 CHEMBL2391065 Bioactive 1-benzylsulfonyl-4-[(3-iodophenyl)methyl]piperazine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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