CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13239
Family Name Gonadotropin-releasing hormone receptor ligand SureCN7899418 family
No. of Seeds 12 No. of Other Members 4
Family Centroid CFAMM00421257 Functional Category Bioactive
Superfamily Gonadotropin-releasing hormone receptor and Beta-lactamase Binder Superfamily
Class Class 173

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
HIV protease Inhibitor Saquinavir Family 64 428
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Setipiprant family 5 118
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Potassium voltage-gated channel subfamily H member 2 Ligand E-... 1 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Platelet-derived growth factor receptor alpha and Platelet-der... 3 3
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Serine/threonine-protein kinase Chk1 Inhibitor BIS-IMIDE A Family 1 3
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 3-phen... 10 27
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Calcitonin gene-related peptide type 1 receptor ligand CHEMBL1... 5 8
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 4 21
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
C-C chemokine receptor type 5 and C-C motif chemokine 5 ligand... 1 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Coagulation factor X and Trypsin-1 inhibitor 2-(5-carbamimidoy... 5 2
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-075TBZ family 2 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 5 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
ALK tyrosine kinase receptor and Insulin receptor ligand 9-eth... 9 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 4 2
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Cytochrome P450 2D6 and Cytochrome P450 2C19 inhibitor Demethy... 1 4
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-... 14 9
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-(piperidin... 1 0
Serine/threonine-protein kinase Chk1 inhibitor (3Z)-6-(2-methy... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN5551829 f... 1 14
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 2 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Motilin receptor ligand SureCN2768052 family 3 0
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Leucine-rich repeat serine/threonine-protein kinase 2 and Plat... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
High affinity nerve growth factor receptor ligand CHEMBL254555... 2 2
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
Telomerase reverse transcriptase inhibitor N-[9-(4-aminoanilin... 1 11
Coagulation factor X and Trypsin-1 inhibitor SureCN6166035 family 1 2
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
KiSS-1 receptor ligand SureCN5132924 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
C-X-C chemokine receptor type 2 and Cytochrome P450 2C9 ligand... 1 7
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 0
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
Histamine H3 receptor ligand SureCN3542210 family 1 0
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Translocator protein inhibitor CHEMBL1672413 family 1 2
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
Kinesin-like protein KIF11 inhibitor 9-(trifluoromethyl)-1,2,4... 4 1
Potassium voltage-gated channel subfamily A member 5 ligand 3-... 1 0
9H-pyrido[3,4-b]indole-3-carboxamide NP (1-(3-bromophenyl)-9h-... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421254 CHEMBL300045 Bioactive SureCN7905605
CFAMM00421270 CHEMBL49578 Bioactive AGN-PC-073Q9D
CFAMM00421262 CHEMBL239108 Bioactive AGN-PC-073Q9E
CFAMM00421269 CHEMBL297918 Bioactive AGN-PC-073Q8Z
CFAMM00421268 CHEMBL297430 Bioactive AGN-PC-073QBV
CFAMM00421267 CHEMBL300268 Bioactive AGN-PC-073Q9F
CFAMM00421265 CHEMBL49891 Bioactive N-[4-[4-[2-[2-(3,5-dimethylphenyl)-5-[2-(2,5-dimethylpyrrolidin-1-yl)-2-oxoethyl]-1H-indol-3-yl]ethylamino]butyl]phenyl]methanesulfonamide
CFAMM00421258 CHEMBL47862 Bioactive AGN-PC-073Q7T
CFAMM00421264 CHEMBL265774 Bioactive SureCN8695101
CFAMM00421257 CHEMBL47761 Bioactive SureCN7899418
CFAMM00421271 CHEMBL45597 Bioactive AGN-PC-073QBU
CFAMM00421263 CHEMBL295152 Bioactive AGN-PC-072Q7F

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23724 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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