CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13257
Family Name Aurora kinase B and Aurora kinase A inhibitor 6-chloro-2-methylsulfonyl-N-[(3E)-3-[5-(morpholin-4-ylmethyl)benzimidazol-2-ylidene]-1,2-dihydropyrazol-4-yl]pyrimidin-4-amine family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00421411 Functional Category Bioactive
Superfamily Aurora kinase A and Aurora kinase B Binder Superfamily 8
Class Class 3568

Cousin Family NamesSeedsMembers
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Tyrosine-protein kinase JAK2 Inhibitor LY2784544 Family 1 1
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421412 CHEMBL2392112 Bioactive 6-chloro-N-[(3E)-3-(5-methylbenzimidazol-2-ylidene)-1,2-dihydropyrazol-4-yl]-2-methylsulfonylpyrimidin-4-amine
CFAMM00421411 CHEMBL2392111 Bioactive 6-chloro-2-methylsulfonyl-N-[(3E)-3-[5-(morpholin-4-ylmethyl)benzimidazol-2-ylidene]-1,2-dihydropyrazol-4-yl]pyrimidin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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