CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13268
Family Name Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhibitor 1-[2-methyl-6-(methylamino)pyrimidin-4-yl]-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00254075 Functional Category Bioactive
Superfamily Cytochrome P450 2C9 and Bifunctional epoxide hydrolase 2 Binder Superfamily 2
Class Class 4537

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
GDC-0349 family 44 77
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-amin... 2 30
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Prothrombin inhibitor SureCN7371121 family 13 3
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand N-(1-... 2 6
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Substance-P receptor ligand Netupitant family 5 2
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
Transient receptor potential cation channel subfamily V member... 57 4
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-[2-(trif... 1 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 8 6
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Transient receptor potential cation channel subfamily V member... 1 0
Transient receptor potential cation channel subfamily V member... 3 2
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421474 CHEMBL2392694 Bioactive 1-[4-(methylamino)-6-phenyl-1,3,5-triazin-2-yl]-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide
CFAMM00421476 CHEMBL2392704 Bioactive 1-[4-methyl-6-(methylamino)pyridin-2-yl]-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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