CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13279
Family Name Acetylcholinesterase inhibitor N-[6-[4-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]butylamino]-6-oxohexyl]-2-(2,3-dimethylanilino)benzamide family
No. of Seeds 9 No. of Other Members 0
Family Centroid CFAMM00421523 Functional Category Bioactive
Superfamily Histone deacetylase 6 and Histone deacetylase 1 Binder Superfamily
Class Class 1555

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
D(3) dopamine receptor Ligand SB-277011 Family 13 178
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Setipiprant family 5 118
ABC294640 family 5 75
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Vasopressin V2 receptor and Vasopressin V1a receptor ligand [2... 2 5
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 4 21
Cellular tumor antigen p53 and Ferritin light chain inhibitor ... 1 2
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Substance-P receptor ligand AGN-PC-004REJ family 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
Mitogen-activated protein kinase 14 inhibitor SureCN14185127 f... 2 0
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421524 CHEMBL2393225 Bioactive N-[4-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptylamino]-4-oxobutyl]-2-(2,3-dimethylanilino)benzamide
CFAMM00421517 CHEMBL2393111 Bioactive N-[6-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexylamino]-6-oxohexyl]-2-(2,3-dimethylanilino)benzamide
CFAMM00421523 CHEMBL2393107 Bioactive N-[6-[4-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]butylamino]-6-oxohexyl]-2-(2,3-dimethylanilino)benzamide
CFAMM00421522 CHEMBL2393109 Bioactive N-[3-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexylamino]-3-oxopropyl]-2-(2,3-dimethylanilino)benzamide
CFAMM00421521 CHEMBL2393108 Bioactive N-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-2-(2,3-dimethylanilino)benzamide
CFAMM00421520 CHEMBL2393228 Bioactive N-[9-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]nonyl]-2-(2,3-dimethylanilino)benzamide
CFAMM00421519 CHEMBL2393229 Bioactive N-[10-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]decyl]-2-(2,3-dimethylanilino)benzamide
CFAMM00421525 CHEMBL2393224 Bioactive N-[3-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptylamino]-3-oxopropyl]-2-(2,3-dimethylanilino)benzamide
CFAMM00421518 CHEMBL2393227 Bioactive N-[8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]-2-(2,3-dimethylanilino)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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