CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13282
Family Name 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine receptor 2A ligand N-(3-methoxyphenyl)-6-(4-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00421550 Functional Category Bioactive
Superfamily cAMP and Glucokinase Binder Superfamily
Class Class 855

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
AP26113 family 16 90
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Ibrutinib family 2 27
MK-6096 family 3 69
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 1 1
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Vascular endothelial growth factor receptor 2 ligand F3284-701... 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 3
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 5
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ITK/TS... 1 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Fibroblast growth factor receptor 1 and Vascular endothelial g... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Glucose-dependent insulinotropic receptor ligand 2-[1-(5-ethyl... 2 1
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Adenosine receptor A1 ligand ethyl 1-(2-chloro-2-phenylethyl)-... 5 1
Transient receptor potential cation channel subfamily V member... 2 4
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Motilin receptor ligand SureCN2012437 family 4 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Mitogen-activated protein kinase 1 inhibitor 1-[(3R)-1-[(2-flu... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Substance-P receptor ligand (2S,3S)-N-[[2-methoxy-5-(tetrazol-... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Cyclin-dependent kinase 1 inhibitor N-[[5-[(3Z)-3-[4-(methoxym... 3 7
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Tyrosine-protein kinase SYK and Lysine--tRNA ligase inhibitor ... 8 8
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor Sure... 2 6
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0
Casein kinase II subunit alpha inhibitor N-[3-[[8-cyano-4-(3-e... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421552 CHEMBL256043 Bioactive 1-[4-(3-amino-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-(3-methoxyphenyl)urea
CFAMM00421550 CHEMBL2393402 Bioactive N-(3-methoxyphenyl)-6-(4-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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