CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13296
Family Name Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-2-[(8R)-1-chloro-3-ethyl-8-[[4-(trifluoromethyl)phenoxy]methyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00421662 Functional Category Bioactive
Superfamily Orexin receptor type 2 and Orexin receptor type 1 Binder Superfamily 2
Class Class 1526

Cousin Family NamesSeedsMembers
Eluxadoline family 4 85
Renin Inhibitor Enalkiren Family 56 44
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3


External ID

Functional Category

Molecule Name

CFAMM00421663 CHEMBL2396863 Bioactive (2R)-2-[(8R)-1-chloro-3-ethyl-8-[[3-(trifluoromethyl)phenoxy]methyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide
CFAMM00421662 CHEMBL2396862 Bioactive (2R)-2-[(8R)-1-chloro-3-ethyl-8-[[4-(trifluoromethyl)phenoxy]methyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide
CFAMM00421660 CHEMBL2396865 Bioactive (2R)-2-[(8S)-1-chloro-8-[2-[4-(difluoromethoxy)phenyl]ethyl]-3-ethyl-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide
CFAMM00421659 CHEMBL2396842 Bioactive (2R)-2-[(8S)-1-chloro-3-cyclopropyl-8-[2-[4-(difluoromethoxy)-3-fluorophenyl]ethyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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