CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13298
Family Name D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A ligand AGN-PC-046V8G family
No. of Seeds 2 No. of Other Members 10
Family Centroid CFAMM00179652 Functional Category Bioactive with Natural Product
Superfamily D(2) dopamine receptor and Alpha-1D adrenergic receptor Binder Superfamily
Class Class 110

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 7 23
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Extracellular calcium-sensing receptor Ligand 2-furan-2-yl-3-p... 4 119
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxy-phenyl)-... 1 3
Poly [ADP-ribose] polymerase 1 Inhibitor 8-methoxy-2-phenyl-3h... 4 6
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 7 12
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 1
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Vasopressin V1b receptor ligand AGN-PC-09QGT9 family 4 123
Vasopressin V1b receptor ligand AGN-PC-00HJ2S family 4 6
Mitogen-activated protein kinase 14 inhibitor N-[(2R)-1-amino-... 2 3
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 5 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Mitogen-activated protein kinase 14 inhibitor N-[4-methyl-3-[6... 1 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor SureC... 2 3
C-X-C chemokine receptor type 3 ligand N-(2-ethoxyethyl)-N-[(1... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
Ghrelin/growth hormone secretagogue receptor and Cytochrome P4... 5 20
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 9 18
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 16 2
Histamine H3 receptor ligand AGN-PC-03Z8FM family 5 0
Histamine H3 receptor ligand AGN-PC-00AE5Q family 13 13
Histamine H3 receptor and Potassium voltage-gated channel subf... 28 30
Histamine H3 receptor ligand AGN-PC-03Z8HJ family 4 1
5-hydroxytryptamine receptor 7 ligand 4-[4-(2-ethoxyphenyl)pip... 2 5
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421679 CHEMBL347623 Bioactive 3-amino-2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylsulfanyl]quinazolin-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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