CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM133
Family Name Dual specificity mitogen-activated protein kinase kinase 1 inhibitor AGN-PC-074U4K family
No. of Seeds 10 No. of Other Members 54
Family Centroid CFAMM00307809 Functional Category Bioactive
Superfamily Vascular endothelial growth factor receptor 2 and Dual specificity mitogen-activated protein kinase kinase 1 Binder Superfamily
Class Class 481

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Receptor-type tyrosine-protein kinase FLT3 ligand 2-(6,7-dimet... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 4 2
Deoxycytidine kinase inhibitor 2-[5-[4-[(4,6-diaminopyrimidin-... 14 11
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
Serine/threonine-protein kinase ATR inhibitor 4-[2-(6-methoxy-... 1 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00307786 CHEMBL323515 Bioactive 3-cyanoquinoline, 4
CFAMM00307825 CHEMBL447167 Bioactive 3-cyanoquinoline, 29
CFAMM00307824 CHEMBL105642 Bioactive 4-[3-chloro-4-(1-methylimidazol-2-yl)sulfanylanilino]-6-methoxy-7-[3-(1-oxo-1,4-thiazinan-4-yl)propoxy]quinoline-3-carbonitrile
CFAMM00307797 CHEMBL105220 Bioactive 4-[3-bromo-4-(1-methylimidazol-2-yl)sulfanylanilino]-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinoline-3-carbonitrile
CFAMM00307816 CHEMBL321045 Bioactive SureCN4454660
CFAMM00307809 CHEMBL106489 Bioactive AGN-PC-074U4K
CFAMM00307783 CHEMBL318804 Bioactive 3-cyanoquinoline, 8
CFAMM00307776 CHEMBL103045 Bioactive 3-cyanoquinoline, 3
CFAMM00307801 CHEMBL322857 Bioactive 3-cyanoquinoline, 7
CFAMM00307774 CHEMBL102374 Bioactive 4-[3-chloro-4-(1,4,5-trimethylimidazol-2-yl)sulfanylanilino]-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinoline-3-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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