CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13322
Family Name C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phenyl]-N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00421806 Functional Category Bioactive
Superfamily Melanocortin receptor 4 and C-C chemokine receptor type 1 Binder Superfamily
Class Class 703

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Glycine receptor subunit beta Ligand Gw 468816 Family 4 67
Neuromedin-K receptor Ligand Osanetant Family 38 192
Motilin receptor Ligand GSK962040 Family 30 457
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
K-604 family 4 71
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 2 7
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 18
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
Rho-associated protein kinase 2 inhibitor N-(7-chloro-1-oxo-2H... 13 42
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
E3 ubiquitin-protein ligase Mdm2 inhibitor (2'R,3R,3'S,5'S)-6-... 17 51
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
Lethal factor inhibitor (2R)-6-[(4-chlorophenyl)methylamino]-2... 3 0
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-5-amino-2-c... 3 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 6
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 3
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Cellular tumor antigen p53 and Inositol monophosphatase 1 inhi... 1 12
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
Mitogen-activated protein kinase 14 inhibitor 4-chloro-N-cyclo... 2 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 2 2
B1 bradykinin receptor ligand 4-(4-methyl-1-oxophthalazin-2-yl... 5 27
Melanocortin receptor 5 and Melanocyte-stimulating hormone rec... 3 23
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4796979 f... 5 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Testosterone 17-beta-dehydrogenase 3 inhibitor AGN-PC-00CHN2 f... 3 2
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 3 0
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor AGN-PC-050YNC family 1 6
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
Melanin-concentrating hormone receptor 1 ligand 3-chloro-5-[4-... 2 0
Mitogen-activated protein kinase 14 inhibitor 3-(2,4-difluoroa... 6 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(2R,3R)-3-(4-c... 1 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
Melanocortin receptor 4 ligand SureCN4532266 family 8 0
Substance-K receptor and Neuromedin-K receptor ligand 1-benzyl... 3 10
Glutamate receptor ionotropic, NMDA 1 ligand CHEMBL40730 family 4 1
C-C chemokine receptor type 3 ligand SureCN3935453 family 4 11
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Mitogen-activated protein kinase 14 inhibitor 5-(2-chloro-4-fl... 3 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 8
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Urotensin-2 receptor and Kappa-type opioid receptor ligand Sur... 2 0
C-C chemokine receptor type 1 ligand (2R)-2-N-[(4-chlorophenyl... 1 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
P2X purinoceptor 7 inhibitor (2S)-2-[5-[[2-(1-adamantyl)acetyl... 1 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Cannabinoid receptor 1 ligand SureCN14463736 family 2 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 4 6
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 3
Melanin-concentrating hormone receptor 1 ligand 2-[1-(1-cyclop... 1 0
Transient receptor potential M8 protein ligand 1-[(2S)-2-(2-ch... 4 2
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 4 2
C-X-C chemokine receptor type 3 ligand N-[3-[7-chloro-3-[2-(4-... 1 0
P2X purinoceptor 7 inhibitor 2-(4-chlorophenyl)-N-[1-[(Z)-[(cy... 1 0
E3 ubiquitin-protein ligase Mdm2 inhibitor SureCN5171589 family 10 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421808 CHEMBL418588 Bioactive SureCN8007125
CFAMM00421806 CHEMBL2398764 Bioactive 3-[2-(carbamoylamino)phenyl]-N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27273 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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