CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13326
Family Name 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor ligand 3,4-dimethyl-1-[4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]cyclohexyl]pyrrolidine-2,5-dione family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00421818 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 1A and Substance-P receptor Binder Superfamily
Class Class 67

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Mu-type opioid receptor ligand opiate Remifentanil Family 10 24
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Benzodiazepine receptor ligand benzodiazepine derivative Fluni... 2 22
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Serum albumin Inhibitor Ebselen Family 3 62
Motilin receptor Ligand GSK962040 Family 30 457
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Vasopressin-neurophysin 2-copeptin Inhibitor Niravoline Family 7 45
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 5 5
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
B2 bradykinin receptor ligand AGN-PC-074WA4 family 2 3
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 5 14
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 10
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
Thyroid hormone receptor beta and DNA-(apurinic or apyrimidini... 1 0
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
Androgen receptor ligand CHEMBL182412 family 2 8
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Somatostatin receptor type 1 ligand AGN-PC-078XL6 family 9 9
Nociceptin receptor and Mu-type opioid receptor ligand spiropi... 1 0
5-hydroxytryptamine receptor 1A ligand CHEBI:643256 family 1 2
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Kappa-type opioid receptor ligand 2-[2-[bis(methylsulfonyl)ami... 2 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Voltage-dependent L-type calcium channel subunit alpha-1S liga... 1 0
Substance-P receptor ligand AGN-PC-01XQZB family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421818 CHEMBL240111 Bioactive 3,4-dimethyl-1-[4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]cyclohexyl]pyrrolidine-2,5-dione
CFAMM00421817 CHEMBL356128 Bioactive 3-benzhydrylidene-1-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]pyrrolidine-2,5-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26831 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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