CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13335
Family Name Mitogen-activated protein kinase 14 and Mitogen-activated protein kinase 11 inhibitor AGN-PC-0D3QPE family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00219159 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Mitogen-activated protein kinase 11 Binder Superfamily
Class Class 718

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
D(3) dopamine receptor Ligand SB-277011 Family 13 178
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Transient receptor potential cation channel subfamily V member... 6 23
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Cysteine protease and Cruzipain inhibitor N-[(E,3S)-1-(benzene... 1 1
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Sonic hedgehog protein inhibitor 3-chloro-N-[4-(methylamino)cy... 2 3
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1231206 ... 6 7
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-073U... 3 8
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Gonadotropin-releasing hormone receptor ligand 1-[4-[1-[(2,6-d... 8 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 8 4
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Histone deacetylase 1 inhibitor N-hydroxy-5-[1-[2-[(1-methylin... 4 1
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Intercellular adhesion molecule 1 and E-selectin inhibitor Sur... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Gamma-aminobutyric acid receptor subunit alpha-2 and Gamma-ami... 6 4
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Histone deacetylase 1 and Potassium voltage-gated channel subf... 3 2
Protein kinase C theta type and Tyrosine-protein kinase Fyn in... 4 0
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand N-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421851 CHEMBL2401999 Bioactive AGN-PC-0D3QQC

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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