CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13337
Family Name Nociceptin receptor and Delta-type opioid receptor ligand spiropiperidine analogue, 26 family
No. of Seeds 25 No. of Other Members 9
Family Centroid CFAMM00095440 Functional Category Bioactive
Superfamily Nociceptin receptor and Mu-type opioid receptor Binder Superfamily 8
Class Class 2396

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Dopamine receptor Ligand Domperidone Family 2 21
Alpha adrenergic receptor Ligand Droperidol Family 20 244
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
B2 bradykinin receptor ligand AGN-PC-074WA4 family 2 3
Cannabinoid receptor 2 ligand SureCN738026 family 5 68
E3 ubiquitin-protein ligase Mdm2 inhibitor (2'R,3R,3'S,5'S)-6-... 17 51
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Lethal factor inhibitor (2R)-6-[(4-chlorophenyl)methylamino]-2... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 6
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Melanocortin receptor 4 and Melanocortin receptor 5 ligand 3-[... 18 26
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 3 0
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
Melanin-concentrating hormone receptor 1 ligand 3-chloro-5-[4-... 2 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(... 5 1
5-hydroxytryptamine receptor 7 ligand 7-chloro-3-[4-[4-(4-chlo... 2 0
Substance-K receptor and Neuromedin-K receptor ligand SureCN78... 2 4
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 2
Mu-type opioid receptor and Nociceptin receptor ligand SureCN8... 7 1
Substance-K receptor and Neuromedin-K receptor ligand 1-benzyl... 3 10
Glutamate receptor ionotropic, NMDA 1 ligand CHEMBL40730 family 4 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 1 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Melanocortin receptor 4 ligand 2-amino-N-[(2R)-3-(2,4-dichloro... 5 5
Nociceptin receptor and Mu-type opioid receptor ligand spiropi... 1 0
C-C chemokine receptor type 1 ligand (2R)-2-N-[(4-chlorophenyl... 1 1
Calcitonin gene-related peptide type 1 receptor and Dual speci... 4 0
Progesterone receptor ligand SureCN3031001 family 8 40
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Integrin alpha-L inhibitor SureCN6314317 family 2 1
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Smoothened homolog inhibitor N-(2,6-dichloro-4-methylsulfonylp... 2 0
Smoothened homolog inhibitor N-(2,6-dichloro-4-cyanophenyl)-1,... 4 3
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 7 1
Transient receptor potential M8 protein ligand 1-[(2S)-2-(2-ch... 4 2
Aldose reductase inhibitor Spiro-cimqat family 6 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421869 CHEMBL464191 Bioactive AGN-PC-04XL8V
CFAMM00421867 CHEMBL464192 Bioactive AGN-PC-04XL8W
CFAMM00421873 CHEMBL473904 Bioactive spiropiperidine analogue, 50
CFAMM00421872 CHEMBL457451 Bioactive spiropiperidine analogue, 37

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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