CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13359
Family Name G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibitor 2-N-(4-aminocyclohexyl)-9-cyclopentyl-6-N-[[6-(furan-3-yl)pyridin-3-yl]methyl]purine-2,6-diamine family
No. of Seeds 1 No. of Other Members 4
Family Centroid CFAMM00270288 Functional Category Bioactive
Superfamily G1/S-specific cyclin-E1 and Binder Superfamily
Class Class 622

Cousin Family NamesSeedsMembers
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Sodium-dependent serotonin transporter Inhibitor 4-furan-2-yl-... 2 10
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 6
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 7 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Glycogen synthase kinase-3 beta inhibitor 2-(furan-3-yl)-N-[2-... 3 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Tyrosine-protein kinase ITK/TSK and Aurora kinase B inhibitor ... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Cysteine protease and Cathepsin L1 inhibitor AGN-PC-076NDO family 1 0
G1/S-specific cyclin-E2 and G1/S-specific cyclin-E1 inhibitor ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26380 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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