CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13362
Family Name Proto-oncogene tyrosine-protein kinase receptor Ret and Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[[5-(3-aminopropanoyl)-1,4,6,7-tetrahydropyrrolo[3,2-c]pyridin-2-yl]methylidene]-5-methoxy-1H-indol-2-one family
No. of Seeds 5 No. of Other Members 14
Family Centroid CFAMM00293598 Functional Category Bioactive with Natural Product
Superfamily Vascular endothelial growth factor receptor 2 and Glycogen synthase kinase-3 beta Binder Superfamily
Class Class 2498

Cousin Family NamesSeedsMembers
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Integrin beta-3 Inhibitor L-756568 Family 8 59
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 2 101
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Cyclin-dependent kinase 2 and G1/S-specific cyclin-E1 Inhibito... 5 1
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 4 4
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Renin inhibitor SureCN1144364 family 3 15
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Renin inhibitor AGN-PC-09M9MJ family 2 23
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 5
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
NS5B protein inhibitor AC1O5AET family 3 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Transient receptor potential cation channel subfamily V member... 1 5
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 1 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 1 3
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Cyclin-dependent kinase 2 and Vascular endothelial growth fact... 1 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 1 8
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Histamine H3 receptor ligand SureCN1397929 family 1 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 18000... 1 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
Histone deacetylase 1 inhibitor (2S)-2-[[2-(5-methoxy-2-methyl... 2 2
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 1
Glycogen synthase kinase-3 beta and G2/mitotic-specific cyclin... 3 0
Bile acid receptor ligand SureCN1243717 family 1 4
Telomerase reverse transcriptase inhibitor N-[9-(4-methoxyanil... 2 0
NP (7,8-dimethoxy-3-methyl-2,3-dihydro-1h-benzo[d]azepin-4-yl)... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421984 CHEMBL2403371 Bioactive (3Z)-3-[(5-acetyl-3-chloro-1,4,6,7-tetrahydropyrrolo[3,2-c]pyridin-2-yl)methylidene]-5-methoxy-1H-indol-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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