CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13392
Family Name Serine/threonine-protein kinase PLK4 inhibitor 4-[(E)-2-[6-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-indazol-3-yl]ethenyl]benzoic acid family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00422170 Functional Category Bioactive
Superfamily Cytochrome P450 3A4 and Cytochrome P450 2C9 Binder Superfamily
Class Class 3249

Cousin Family NamesSeedsMembers
Macrophage colony-stimulating factor 1 Inhibitor ABT-869 Family 8 56
Hydroxycarboxylic acid receptor 2 Ligand 5-benzyl-1h-pyrazole-... 5 36
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 3
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 19 40
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
Cannabinoid receptor 2 ligand [(4S,4aR,8aS)-4-hydroxy-4-phenyl... 2 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 8 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 3
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 5
Serine/threonine-protein kinase Chk1 inhibitor SureCN6786833 f... 4 6
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Hydroxycarboxylic acid receptor 2 ligand AGN-PC-07ZGHO family 1 1


External ID

Functional Category

Molecule Name

CFAMM00422170 CHEMBL2407744 Bioactive 4-[(E)-2-[6-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-indazol-3-yl]ethenyl]benzoic acid
CFAMM00422166 CHEMBL483352 Bioactive SureCN14349869

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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