CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13394
Family Name Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-3-[[3-[(E)-2-pyridin-3-ylethenyl]-1H-indazol-6-yl]methylidene]-1H-indol-2-one family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00422181 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase PLK4 and cAMP Binder Superfamily
Class Class 842

Cousin Family NamesSeedsMembers
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
DCC-2036 family 2 5
Indeglitazar family 3 39
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 2 101
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Phospholipase A2 Inhibitor Hyrtiosulawesine Family 1 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 4 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 4 3
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 19 40
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 5 19
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 7
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
DNA gyrase subunit B inhibitor N-ethyl-5-[6-methoxy-5-(2-oxo-3... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 1 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 1 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Hepatocyte growth factor receptor ligand AGN-PC-00AG7Q family 1 10
Wee1-like protein kinase and Serine/threonine-protein kinase C... 8 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Coagulation factor X inhibitor 2-(4-methoxyphenyl)-N-[5-(2-sul... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor 1-(4-methoxyphenyl)-3... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 3 0
1-[(5-hydroxy-1H-indol-3-yl)methyl]-5'-methyl-5-phenylspiro[1,... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00422183 CHEMBL2407895 Bioactive (3E)-3-[[(3E)-3-[2-(1H-pyridin-4-ylidene)ethylidene]-1,2-dihydroindazol-6-yl]methylidene]indole-2,5-dione
CFAMM00422182 CHEMBL2407894 Bioactive (3E)-5-methoxy-3-[[3-[(E)-2-pyridin-4-ylethenyl]-1H-indazol-6-yl]methylidene]-1H-indol-2-one
CFAMM00422181 CHEMBL2407748 Bioactive (3E)-5-methoxy-3-[[3-[(E)-2-pyridin-3-ylethenyl]-1H-indazol-6-yl]methylidene]-1H-indol-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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