CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13413
Family Name Diacylglycerol O-acyltransferase 1 inhibitor 4-[5-[5-(1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00422240 Functional Category Bioactive
Superfamily and Serine/threonine-protein kinase TBK1 Binder Superfamily
Class Class 227

Cousin Family NamesSeedsMembers
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0


External ID

Functional Category

Molecule Name

CFAMM00422240 CHEMBL2408634 Bioactive 4-[5-[5-(1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid
CFAMM00422239 CHEMBL2408630 Bioactive 4-[5-[5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid
CFAMM00422249 CHEMBL2408623 Bioactive 4-[5-[5-[6-(trifluoromethoxy)-1H-benzimidazol-2-yl]pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid
CFAMM00422237 CHEMBL2408632 Bioactive 4-[5-[5-(6-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid
CFAMM00422247 CHEMBL2408621 Bioactive 4-[5-[5-(6-cyano-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid
CFAMM00422243 CHEMBL2408472 Bioactive 4-[5-[5-(5,6-difluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid
CFAMM00422242 CHEMBL2408470 Bioactive 4-[5-[5-(6-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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