CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13451
Family Name Peroxisome proliferator-activated receptor delta and Peroxisome proliferator-activated receptor gamma ligand 3-[4-[(3R)-3-(4-chloro-2-pyridin-2-ylphenoxy)butoxy]-2-methylphenyl]propanoic acid family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00231584 Functional Category Bioactive
Superfamily Pyruvate kinase PKM and Nuclear receptor ROR-gamma Binder Superfamily
Class Class 3170

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Proteinase-activated receptor 1 Ligand SCH-530348 Family 20 215
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Arachidonate 5-lipoxygenase-activating protein Inhibitor AM103... 14 12
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Renin Inhibitor CP-305202 Family 9 30
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 15 28
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Leukotriene B4 receptor 1 ligand AGN-PC-04XM3V family 3 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
Cellular tumor antigen p53 and Lethal(3)malignant brain tumor-... 1 6
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Endothelin-1 receptor ligand SureCN8118632 family 4 5
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Retinoic acid receptor RXR-alpha ligand 6-[(3-butoxy-5,5,8,8-t... 2 2
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 2 3
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Peroxisome proliferator-activated receptor delta and Peroxisom... 22 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 9 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 1
Thromboxane-A synthase inhibitor (E)-7-[4-[5-[(2S,4S,5R)-5-[(Z... 3 9
Thromboxane-A synthase inhibitor SureCN9045578 family 1 12
Proteinase-activated receptor 1 ligand ethyl N-[(1R,3aR,4aR,6R... 1 4
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Cysteinyl leukotriene receptor 1 ligand 2-[2-[5-[[3-[(E)-2-(6,... 1 8
Bile acid receptor ligand pyridin-4-yl (1R,3aS,5aR,5bR,7aR,9S,... 1 0
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Free fatty acid receptor 1 ligand AGN-PC-0A9RM5 family 1 0
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 1
Histamine H1 receptor and Histamine H2 receptor ligand SureCN6... 1 3
Histamine H1 receptor and Histamine H2 receptor ligand SureCN5... 3 6
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 2 1
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 3
7-(4-hydroxy-2-oxo-2H-chromen-3-yl)chromeno[4',3':3,4]cyclopen... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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