CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13467
Family Name Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1-tert-butyltetrazol-5-yl)-(diethylamino)methyl]phenyl]-7-chloroquinolin-4-amine family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00362580 Functional Category Bioactive
Superfamily Microtubule-associated protein tau and Prelamin-A/C Binder Superfamily 10
Class Class 1567

Cousin Family NamesSeedsMembers
Benzodiazepine receptor Ligand Midazolam Family 5 160
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 2
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Vascular endothelial growth factor receptor 2 and Fibroblast g... 5 2
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 2 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Cyclin-dependent kinase 2 and MAP kinase-activated protein kin... 3 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 9 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Serine/threonine-protein kinase PLK1 inhibitor 2-amino-pyrazol... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48686 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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