CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1348
Family Name Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 family
No. of Seeds 11 No. of Other Members 13
Family Centroid CFAMM00322392 Functional Category Bioactive
Superfamily Integrin alpha-V and Integrin beta-3 Binder Superfamily 2
Class Class 898

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Substance-P receptor Ligand GSK424887 Family 8 184
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
JAK Inhibitor Momelotinib Family 33 83
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin beta-3 Inhibitor Elarofiban Family 28 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-03RR5Q f... 3 2
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Coagulation factor X inhibitor (2S)-(3'-AMIDINO-3-BIPHENYL)-5-... 1 0
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-quinolin... 6 8
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-... 3 0
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Carboxypeptidase B2 and Carboxypeptidase B inhibitor 3-(6-amin... 5 10
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6359092 f... 9 5
Integrin beta-3 and Integrin alpha-IIb inhibitor 3-[[1-(3-pipe... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 1
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-(benzene... 3 2
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[5-methy... 4 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 11 0
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN8335217 f... 2 1
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-00BBPN f... 2 3
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Integrin beta-3 and Integrin alpha-V inhibitor SureCN2833591 f... 4 6
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 7 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-00IW9E f... 3 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[3-(2... 4 2
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[4-(... 3 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[2-[(... 3 1
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-3-[4-[4-[[... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00322384 CHEMBL83558 Bioactive (3S)-3-quinolin-3-yl-3-[6-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)hexanoylamino]propanoic acid
CFAMM00322382 CHEMBL336830 Bioactive SureCN3888493
CFAMM00322388 CHEMBL310518 Bioactive (3S)-3-quinolin-3-yl-3-[[2-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butanoylamino]acetyl]amino]propanoic acid
CFAMM00322381 CHEMBL301131 Bioactive (3S)-3-[[2-[3-chloro-2-cyclopropyl-6-oxo-5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyrazin-1-yl]acetyl]amino]-3-quinolin-3-ylpropanoic acid
CFAMM00322374 CHEMBL83225 Bioactive (3S)-3-quinolin-3-yl-3-[7-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)heptanoylamino]propanoic acid
CFAMM00322373 CHEMBL116123 Bioactive SureCN7553511
CFAMM00322379 CHEMBL79248 Bioactive SureCN6420863
CFAMM00322392 CHEMBL334984 Bioactive SureCN3888804

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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