CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13482
Family Name Tyrosine-protein kinase JAK2 inhibitor [4-[[5-(1-ethylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]pyridin-2-yl]methanol family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00422559 Functional Category Bioactive
Superfamily Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibitor Sch 727965 Superfamily
Class Class 1134

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Vascular endothelial growth factor receptor 2 Ligand Ptk787/zk... 5 38
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 2
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
SCH-900776 family 8 14
PF-4217903 family 14 65
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Tyrosine kinase Inhibitor PKI166 Family 17 198
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Beta-3 adrenergic receptor ligand N-[4-[2-[[(2R)-2-hydroxy-2-p... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 13
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 5
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Adenosine kinase inhibitor N-cyclopropyl-2-[[1-[(2R,3R,4S,5R)-... 4 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 3
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Protein kinase C theta type and Protein kinase C delta type in... 2 1
Protein kinase C theta type and Protein kinase C delta type in... 9 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00422559 CHEMBL2414531 Bioactive [4-[[5-(1-ethylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]pyridin-2-yl]methanol
CFAMM00422562 CHEMBL2414549 Bioactive [4-[[5-(3-propan-2-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]pyridin-2-yl]methanol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

25240 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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