CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13486
Family Name Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(1-propan-2-ylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzoic acid family
No. of Seeds 5 No. of Other Members 6
Family Centroid CFAMM00422582 Functional Category Bioactive
Superfamily Cyclin-A2 and AMP deaminase 3 Binder Superfamily
Class Class 307

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Aurora kinase A Inhibitor MLN8054 Family 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Cartazo... 11 105
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 1-methyl-8-(... 1 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 16 34
Type-1 angiotensin II receptor ligand SureCN9527437 family 2 34
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Dipeptidyl peptidase 4 inhibitor 3-[6-[(3R,4S)-3-amino-4-(2,4,... 3 7
Mitogen-activated protein kinase 14 inhibitor methyl 4-[5-(eth... 3 11
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 2-[3-[... 1 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6i family 1 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Mitogen-activated protein kinase 14 inhibitor ethyl 4-[5-[(3-f... 2 0
Type-1 angiotensin II receptor ligand 2-ethyl-4-[[4-[2-(2H-tet... 2 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Type-1B angiotensin II receptor and Type-2 angiotensin II rece... 1 1
AMP deaminase 3 inhibitor 4-(2-imidazo[2,1-f][1,2,4]triazin-7-... 1 0
Type-1B angiotensin II receptor ligand SureCN9310003 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00422580 CHEMBL2414540 Bioactive 4-[[8-(1-cyclopentylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzoic acid
CFAMM00422577 CHEMBL2414538 Bioactive 4-[[8-[1-(2-methylpropyl)pyrazol-4-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzoic acid
CFAMM00422576 CHEMBL2414539 Bioactive 4-[[8-(2-propan-2-ylpyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzoic acid
CFAMM00422582 CHEMBL2414542 Bioactive 4-[[8-(1-propan-2-ylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzoic acid
CFAMM00422581 CHEMBL2414541 Bioactive 4-[[8-(1-cyclohexylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27271 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543