CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1353
Family Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor AC1O5RQK family
No. of Seeds 18 No. of Other Members 10
Family Centroid CFAMM00056951 Functional Category Bioactive
Superfamily 3-hydroxy-3-methylglutaryl-coenzyme A reductase Binder Superfamily 2
Class Class 716

Cousin Family NamesSeedsMembers
3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Fluv... 6 53
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 44
Thromboxane A2 receptor ligand SureCN9681938 family 3 14
Thromboxane A2 receptor ligand SureCN9681954 family 2 5
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 11 0
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 3 3
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (3R,... 3 3
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00322427 CHEMBL1161656 Bioactive (E,3R,5S)-7-[2,4-bis(4-fluorophenyl)-5-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322426 CHEMBL1161653 Bioactive (E,3R,5S)-7-[5-(3,5-diethyl-4-fluorophenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322439 CHEMBL1161640 Bioactive (E,3R,5S)-7-[5-(3,5-dimethylphenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322445 CHEMBL1161648 Bioactive (E,3R,5S)-7-[2-tert-butyl-4,5-bis(4-fluorophenyl)imidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322425 CHEMBL1161652 Bioactive (E,3R,5S)-7-[2-(dimethylamino)-4,5-bis(4-fluorophenyl)imidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322438 CHEMBL1161641 Bioactive (E,3R,5S)-7-[5-(4-fluorophenyl)-4-(3-methylsulfonylphenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322431 CHEMBL1161639 Bioactive (E,3R,5S)-7-[4,5-bis(4-fluorophenyl)-2-(trifluoromethyl)imidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322444 CHEMBL1161664 Bioactive (E,3R,5S)-7-[5-(3,5-dichlorophenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322437 CHEMBL1161643 Bioactive (E,3R,5S)-7-[4,5-bis(4-fluorophenyl)-2-methylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322450 CHEMBL333760 Bioactive SureCN6240500
CFAMM00322424 CHEMBL1161650 Bioactive (E,3R,5S)-7-[5-(4-fluoro-3,5-dimethylphenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322443 CHEMBL1161662 Bioactive (E,3R,5S)-7-[5-(4-fluorophenyl)-2-propan-2-yl-4-pyridin-3-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322436 CHEMBL1161645 Bioactive (E,3R,5S)-7-[5-(4-fluoro-2-methylphenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322442 CHEMBL1161663 Bioactive GTPL3000
CFAMM00322435 CHEMBL1161647 Bioactive (E,3R,5S)-7-[5-(4-fluorophenyl)-4-[3-(methylamino)phenyl]-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322428 CHEMBL1161657 Bioactive (E,3R,5S)-7-[4-(4-chloro-3,5-dimethylphenyl)-5-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00322441 CHEMBL1161660 Bioactive (E,3R,5S)-7-[5-(3-chlorophenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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