CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13546
Family Name Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluorophenyl)sulfonylphenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide family
No. of Seeds 6 No. of Other Members 4
Family Centroid CFAMM00422880 Functional Category Bioactive
Superfamily Macrophage metalloelastase Inhibitor PF-00356231 Superfamily
Class Class 1827

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Reverse transcriptase Inhibitor Delavirdine Family 1 68
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Macrophage colony-stimulating factor 1 and Vascular endothelia... 1 1
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Transient receptor potential cation channel subfamily V member... 6 23
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 3-phen... 10 27
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 6 ligand N-[[(1R)-6-(3-fluorophen... 1 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... 3 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Cathepsin L1 and Cathepsin S inhibitor N-[(2S)-4-methyl-1-oxo-... 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 6 6
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(6-morp... 2 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
5-hydroxytryptamine receptor 6 ligand AGN-PC-07CR33 family 2 2
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 4-(5,7... 2 9
C-X-C chemokine receptor type 3 ligand AGN-PC-07ZH3V family 1 1
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,4-dimethylphen... 2 0
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00422886 CHEMBL2420649 Bioactive N-[[4-[3-(trifluoromethyl)phenyl]sulfonylphenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
CFAMM00422885 CHEMBL2420647 Bioactive N-[[4-(3-methylphenyl)sulfonylphenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
CFAMM00422883 CHEMBL2420619 Bioactive N-[[4-(3,4-difluorophenyl)sulfonylphenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
CFAMM00422882 CHEMBL2420670 Bioactive N-[(4-piperidin-1-ylsulfonylphenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
CFAMM00422888 CHEMBL2420620 Bioactive N-[[4-(3,5-difluorophenyl)sulfonylphenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
CFAMM00422880 CHEMBL2420651 Bioactive N-[[4-(3-fluorophenyl)sulfonylphenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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