CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1355
Family Name Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3 ligand 11-[2-[6-[8-[6-[(2-methoxyphenyl)methyl-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]amino]hexyl-methylamino]octyl-methylamino]hexylamino]acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;oxalic acid family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00322505 Functional Category Bioactive
Superfamily DCC-2036 Superfamily
Class Class 918

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Peroxisome proliferator-activated receptor gamma Ligand Piogli... 2 29
Histamine H1 receptor Ligand Mepyramine Family 5 65
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 5 12
Smoothened homolog Inhibitor LDE225 Family 3 76
AP26113 family 16 90
XL-888 family 16 85
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
DNA ligase Inhibitor 7-(4-methoxyphenyl)pteridine-2,4-diol Family 1 4
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 6
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Reverse transcriptase/RNaseH inhibitor Dipyridodiazepinone der... 1 8
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Reverse transcriptase/RNaseH and Cytochrome P450 2C19 inhibito... 7 2
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 1
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Reverse transcriptase/RNaseH inhibitor PETT deriv. 14 family 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Histamine H3 receptor ligand AGN-PC-03Z8HB family 3 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 2 25
Glycogen synthase kinase-3 beta and G1/S-specific cyclin-E2 in... 2 0
Muscarinic acetylcholine receptor M1 ligand N'-[1-ethyl-2-[(E,... 1 0
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
NP N-(1-((3-(1h-imidazol-1-yl)propyl)amino)-3-methyl-1-oxobuta... 2 0
5-(4-methoxyphenyl)-4-oxo-1H-pyrido[2,3-d]pyrimidin-2-olate NP... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00322506 CHEMBL1201997 Bioactive 11-[2-[6-[8-[6-[(2-methoxyphenyl)methylamino]hexyl-methylamino]octyl-methylamino]hexyl-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]amino]acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;oxalic acid
CFAMM00322505 CHEMBL1201996 Bioactive 11-[2-[6-[8-[6-[(2-methoxyphenyl)methyl-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]amino]hexyl-methylamino]octyl-methylamino]hexylamino]acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;oxalic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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