CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13587
Family Name Orexin receptor type 1 and Orexin receptor type 2 ligand (1R,2S)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)-2-[[4-(methoxymethyl)-2-methylpyrimidin-5-yl]oxymethyl]cyclopropane-1-carboxamide family
No. of Seeds 6 No. of Other Members 1
Family Centroid CFAMM00423104 Functional Category Bioactive
Superfamily Gastrin-releasing peptide receptor and Arachidonate 5-lipoxygenase-activating protein Binder Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
SB1518 family 7 103
MK-6096 family 3 69
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Metabotropic glutamate receptor 5 ligand AGN-PC-0DB8TJ family 2 0
Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 liga... 3 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423100 CHEMBL2425783 Bioactive (1R,2S)-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluoro-4-methoxyphenyl)-N-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide
CFAMM00423098 CHEMBL2425788 Bioactive (1R,2S)-N-(5-fluoropyridin-2-yl)-2-[[4-(methoxymethyl)-2-methylpyrimidin-5-yl]oxymethyl]-2-phenylcyclopropane-1-carboxamide
CFAMM00423104 CHEMBL2425785 Bioactive (1R,2S)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)-2-[[4-(methoxymethyl)-2-methylpyrimidin-5-yl]oxymethyl]cyclopropane-1-carboxamide
CFAMM00423103 CHEMBL2425784 Bioactive (1R,2S)-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-N-(5-fluoro-4-methoxypyridin-2-yl)-2-(3-fluorophenyl)cyclopropane-1-carboxamide
CFAMM00423102 CHEMBL2425787 Bioactive (1R,2S)-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-N-(5-fluoro-6-methoxypyridin-2-yl)-2-(3-fluorophenyl)cyclopropane-1-carboxamide
CFAMM00423101 CHEMBL2425786 Bioactive (1R,2S)-N-(5-cyanopyridin-2-yl)-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropane-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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