CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13593
Family Name Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3R)-3-aminopiperidin-1-yl]-1-but-2-ynyl-3-(quinolin-2-ylmethyl)pyrimidine-2,4-dione family
No. of Seeds 7 No. of Other Members 7
Family Centroid CFAMM00423148 Functional Category Bioactive with Natural Product
Superfamily Cytochrome P450 3A4 and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 1189

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Substance-P receptor Ligand TAK-637 Family 18 63
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Cannabinoid receptor 2 ligand 1-[[4-[5-fluoro-6-(piperidin-1-y... 21 2
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Gonadotropin-releasing hormone receptor ligand 6-[(4-chloro-2-... 3 3
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 11
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423153 CHEMBL2425891 Bioactive 6-[(3R)-3-aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-methylquinolin-2-yl)methyl]pyrimidine-2,4-dione
CFAMM00423146 CHEMBL2425889 Bioactive 6-[(3R)-3-aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-chloroquinolin-2-yl)methyl]pyrimidine-2,4-dione
CFAMM00423152 CHEMBL2425890 Bioactive 6-[(3R)-3-aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-fluoroquinolin-2-yl)methyl]pyrimidine-2,4-dione
CFAMM00423151 CHEMBL2425893 Bioactive 6-[(3R)-3-aminopiperidin-1-yl]-1-but-2-ynyl-3-[(7-chloroquinolin-2-yl)methyl]pyrimidine-2,4-dione
CFAMM00423150 CHEMBL2425895 Bioactive 6-[(3R)-3-aminopiperidin-1-yl]-1-but-2-ynyl-3-[(4-chloroquinolin-2-yl)methyl]pyrimidine-2,4-dione
CFAMM00423149 CHEMBL2425894 Bioactive 6-[(3R)-3-aminopiperidin-1-yl]-1-but-2-ynyl-3-[(7-fluoroquinolin-2-yl)methyl]pyrimidine-2,4-dione
CFAMM00423148 CHEMBL2425886 Bioactive 6-[(3R)-3-aminopiperidin-1-yl]-1-but-2-ynyl-3-(quinolin-2-ylmethyl)pyrimidine-2,4-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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