CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13602
Family Name Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]propanamide family
No. of Seeds 10 No. of Other Members 4
Family Centroid CFAMM00423223 Functional Category Bioactive
Superfamily Glucocorticoid receptor and Coagulation factor X Binder Superfamily
Class Class 2728

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 12 108
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Amg 423 family 7 47
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Glucocorticoid receptor and Oxysterols receptor LXR-alpha Liga... 4 13
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Glucocorticoid receptor ligand N-[(3S)-3-[1-(4-fluorophenyl)in... 11 24
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Serine/threonine-protein kinase mTOR and DNA-dependent protein... 6 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 5 11
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)indazol-5-... 16 10
Pol polyprotein inhibitor AC1LAMOI family 12 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Glucocorticoid receptor ligand 6-benzyl-1-(4-fluorophenyl)-4a-... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Progesterone receptor ligand AGN-PC-074LWG family 1 1
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Cell division cycle 7-related protein kinase and Dual specific... 3 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Cathepsin D and Beta-secretase 1 inhibitor N-[(2S,3R)-4-[[2-(2... 4 8
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
P2X purinoceptor 7 inhibitor SureCN1194877 family 1 6
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00GCQW f... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9057529 f... 2 0
Lutropin-choriogonadotropic hormone receptor ligand 5-[2-(4-te... 1 1
TGF-beta receptor type-1 ligand SureCN373106 family 4 1
Extracellular calcium-sensing receptor ligand SureCN2220343 fa... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423221 CHEMBL2426122 Bioactive N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]acetamide
CFAMM00423209 CHEMBL2426126 Bioactive N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]-3,3-dimethylbutanamide
CFAMM00423220 CHEMBL2426123 Bioactive 2,2,2-trifluoro-N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]acetamide
CFAMM00423226 CHEMBL2426109 Bioactive 3,3,3-trifluoro-N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2-methyl-3-phenylpropyl]propanamide
CFAMM00423214 CHEMBL2426111 Bioactive 1-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2,5-trimethylhexyl]-3-(2,2,2-trifluoroethyl)urea
CFAMM00423225 CHEMBL2426128 Bioactive 3,3,3-trifluoro-N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2,5-trimethylhexyl]propanamide
CFAMM00423213 CHEMBL2426113 Bioactive 1-tert-butyl-3-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2,5-trimethylhexyl]urea
CFAMM00423223 CHEMBL2426124 Bioactive 3,3,3-trifluoro-N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]propanamide
CFAMM00423212 CHEMBL2426112 Bioactive 1-tert-butyl-3-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]urea
CFAMM00423222 CHEMBL2426125 Bioactive N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]-2,2-dimethylpropanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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