CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13603
Family Name Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide family
No. of Seeds 5 No. of Other Members 3
Family Centroid CFAMM00423232 Functional Category Bioactive
Superfamily Glucocorticoid receptor Binder Superfamily 11
Class Class 170

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Prothrombin Inhibitor Dabigatran Family 7 182
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Aurora kinase A inhibitor 2-[4-[6-chloro-2-[4-(morpholin-4-ylm... 1 2
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 2 2
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Serine/threonine-protein kinase Chk1 inhibitor 2-indazol-1-yl-... 4 5
Orexin receptor type 2 and Orexin receptor type 1 ligand 6-ami... 3 1
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 6 1
Glucocorticoid receptor ligand 3-[1-(3-chloro-4-fluorophenyl)i... 2 0
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)indazol-5-... 16 10
Glucocorticoid receptor ligand (3R)-3-[1-(4-fluorophenyl)indaz... 4 2
Trans-2-enoyl-ACP reductase II inhibitor AGN-PC-01LWZK family 3 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Platelet-activating factor receptor ligand 1,8-dimethyl-5-[4-(... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Aurora kinase A inhibitor AGN-PC-08002R family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423230 CHEMBL2426139 Bioactive 2,2-dimethyl-3-phenyl-3-(3-phenylimidazo[1,5-a]pyridin-7-yl)-N-(1,3-thiazol-2-yl)propanamide
CFAMM00423236 CHEMBL2426146 Bioactive 3-[1-(2,4-difluorophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
CFAMM00423235 CHEMBL2426143 Bioactive 3-[1-(4-cyanophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
CFAMM00423234 CHEMBL2426141 Bioactive 3-[1-(3-cyanophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
CFAMM00423232 CHEMBL2426137 Bioactive 3-[1-(4-fluorophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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