CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1361
Family Name 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inhibitor (2S,3S,4R,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(ethylsulfanylmethyl)pyrrolidine-3,4-diol family
No. of Seeds 17 No. of Other Members 17
Family Centroid CFAMM00322539 Functional Category Bioactive
Superfamily S-methyl-5'-thioadenosine phosphorylase and 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Binder Superfamily
Class Class 3353

Cousin Family NamesSeedsMembers
Adenosine receptor A1 Ligand SLV320 Family 6 79
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 12 5
Purine nucleoside phosphorylase inhibitor 7-[(3R,4S,5R)-3,4-di... 10 34
Purine nucleoside phosphorylase inhibitor 2-amino-7-[[(2S,4R)-... 5 0
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 7 6
S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN997478... 8 0
S-methyl-5'-thioadenosine phosphorylase inhibitor 1-[(4-amino-... 7 1
S-methyl-5'-thioadenosine phosphorylase inhibitor 2-[[(4-amino... 5 0
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Adenosine receptor A3 ligand (2R,3R,4S)-2-[2-chloro-6-[(3-fluo... 6 7
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Purine nucleoside phosphorylase inhibitor SureCN6345422 family 9 11
Purine nucleoside phosphorylase inhibitor SureCN6353628 family 2 0


External ID

Functional Category

Molecule Name

CFAMM00322550 CHEMBL1161749 Bioactive AGN-PC-042AUU
CFAMM00322552 CHEMBL545042 Bioactive AGN-PC-07BZRK
CFAMM00322536 CHEMBL1241494 Bioactive (2S,3S,4R,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(4-chlorophenyl)sulfanylmethyl]pyrrolidine-3,4-diol
CFAMM00322543 CHEMBL552894 Bioactive AGN-PC-07BZSN
CFAMM00322535 CHEMBL1241493 Bioactive (2S,3S,4R,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(benzylsulfanylmethyl)pyrrolidine-3,4-diol
CFAMM00322551 CHEMBL554896 Bioactive (2S,3S,4R,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(methylsulfanylmethyl)pyrrolidine-3,4-diol;hydrochloride
CFAMM00322557 CHEMBL553982 Bioactive AGN-PC-07BZSE
CFAMM00322548 CHEMBL554322 Bioactive AGN-PC-07BYFA
CFAMM00322534 CHEMBL1195586 Bioactive (2S,3S,4R,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(methylsulfanylmethyl)pyrrolidine-3,4-diol
CFAMM00322540 CHEMBL207655 Bioactive 2-amino-4-[[(2S,3R,4S,5S)-5-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxypyrrolidin-2-yl]methylsulfanyl]butanoic acid
CFAMM00322547 CHEMBL544806 Bioactive AGN-PC-07BZRJ
CFAMM00322539 CHEMBL1242855 Bioactive (2S,3S,4R,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(ethylsulfanylmethyl)pyrrolidine-3,4-diol
CFAMM00322555 CHEMBL544110 Bioactive AGN-PC-07BZRA
CFAMM00322530 CHEMBL545740 Bioactive AGN-PC-07BZRU
CFAMM00322545 CHEMBL542449 Bioactive AGN-PC-07BZS1
CFAMM00322553 CHEMBL554965 Bioactive AGN-PC-07BZSV
CFAMM00322537 CHEMBL542694 Bioactive AGN-PC-07BZS5

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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