CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13618
Family Name Growth hormone secretagogue receptor type 1 and Muscarinic acetylcholine receptor M2 ligand 1-[2-[(1R)-5-(5-ethylpyrimidin-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]-2-(5-methoxypyridin-2-yl)ethanone family
No. of Seeds 3 No. of Other Members 9
Family Centroid CFAMM00423348 Functional Category Bioactive
Superfamily Muscarinic acetylcholine receptor M2 and Growth hormone secretagogue receptor type 1 Binder Superfamily
Class Class 4721

Cousin Family NamesSeedsMembers
Smoothened homolog Inhibitor LDE225 Family 3 76
MK-6096 family 3 69
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5


External ID

Functional Category

Molecule Name

CFAMM00423348 CHEMBL2426685 Bioactive 1-[2-[(1R)-5-(5-ethylpyrimidin-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]-2-(5-methoxypyridin-2-yl)ethanone
CFAMM00423347 CHEMBL2426687 Bioactive 2-(5-methoxypyridin-2-yl)-1-[2-[(1R)-5-(5-methylpyrimidin-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone
CFAMM00423351 CHEMBL2426677 Bioactive 2-(4-methoxyphenyl)-1-[2-[(1R)-5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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