CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13625
Family Name Histamine H3 receptor and Sodium-dependent serotonin transporter ligand SureCN2807229 family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00147937 Functional Category Bioactive
Superfamily Histamine H3 receptor and Sodium-dependent serotonin transporter Binder Superfamily 2
Class Class 1129

Cousin Family NamesSeedsMembers
Calcium-activated potassium channel subunit alpha-1 Ligand Qui... 3 46
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
PF-02545920 family 16 140
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Squalene synthase Inhibitor ER-119884 Family 2 3
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Acetylcholinesterase and Cholinesterase Inhibitor 1,4-di(berbe... 5 0
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Histamine H1 receptor and Potassium voltage-gated channel subf... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Coagulation factor X and Prothrombin inhibitor AGN-PC-0759SH f... 5 4
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Lysosomal Pro-X carboxypeptidase inhibitor 1-(4-chloropyridin-... 6 1
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)... 3 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Renin inhibitor SureCN6043852 family 2 0
Renin inhibitor SureCN6042213 family 2 3
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Nischarin inhibitor SureCN7810370 family 1 0
Coagulation factor X inhibitor JTV-803 free base family 4 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423376 CHEMBL242820 Bioactive SureCN1036087

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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