CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13639
Family Name Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin-4-ylanilino)-5-(trifluoromethyl)pyridin-4-yl]amino]-N-methylbenzamide;hydrochloride family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00423441 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Inhibitor Bay 80-6946 Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Smoothened homolog Inhibitor LDE225 Family 3 76
AP26113 family 16 90
MK-6096 family 3 69
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Growth hormone secretagogue receptor type 1 and Potassium volt... 3 0
Insulin-like growth factor 1 receptor ligand 3-[[2-[2-methoxy-... 2 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
ALK tyrosine kinase receptor and Ribosomal protein S6 kinase a... 6 2
ALK tyrosine kinase receptor and Insulin receptor ligand 7-[[5... 4 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Insulin-like growth factor 1 receptor ligand GSK2110236A family 5 0
Insulin-like growth factor 1 receptor ligand AGN-PC-077MU8 family 2 0
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 2 25
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423441 CHEMBL2430358 Bioactive 2-[[2-(2-methoxy-4-morpholin-4-ylanilino)-5-(trifluoromethyl)pyridin-4-yl]amino]-N-methylbenzamide;hydrochloride
CFAMM00423439 CHEMBL457322 Bioactive AGN-PC-077MUT

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27759 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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