CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13659
Family Name Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dihydro-1,4-benzodioxin-6-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl]quinoline family
No. of Seeds 1 No. of Other Members 5
Family Centroid CFAMM00423540 Functional Category Bioactive
Superfamily Hepatocyte growth factor receptor Ligand Amg 208 Superfamily
Class Class 1248

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
PF-02545920 family 16 140
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YMN ... 7 11
Serine/threonine-protein kinase B-raf inhibitor SureCN1013580 ... 2 0
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 10 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 6 0
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Corticotropin-releasing factor receptor 1 ligand CHEMBL1830528... 1 0
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCL... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 1
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-07CQG5 ... 2 1
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor Sure... 2 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423540 CHEMBL2431829 Bioactive 6-[(1S)-1-[6-(2,3-dihydro-1,4-benzodioxin-6-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl]quinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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