CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13671
Family Name Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,6-dimethylpyrimidin-2-yl)-2-[(5-phenyl-2H-triazol-4-yl)methyl]-2,9-diazaspiro[5.5]undecan-1-one family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00423601 Functional Category Bioactive
Superfamily Cruzipain and Prelamin-A/C Binder Superfamily 3
Class Class 925

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Type-1 angiotensin II receptor Ligand Tasosartan Family 10 29
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
XL-888 family 16 85
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
3-phosphoinositide-dependent protein kinase 1 and Rho-associat... 12 11
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423602 CHEMBL2435397 Bioactive 9-(4,6-dimethylpyrimidin-2-yl)-2-[(4-phenyl-1H-pyrazol-5-yl)methyl]-2,9-diazaspiro[5.5]undecan-1-one
CFAMM00423601 CHEMBL2435396 Bioactive 9-(4,6-dimethylpyrimidin-2-yl)-2-[(5-phenyl-2H-triazol-4-yl)methyl]-2,9-diazaspiro[5.5]undecan-1-one
CFAMM00423600 CHEMBL2435395 Bioactive 9-(4,6-dimethylpyrimidin-2-yl)-2-[(2-methyl-5-phenyltriazol-4-yl)methyl]-2,9-diazaspiro[5.5]undecan-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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