CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13672
Family Name Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,6-dimethylpyrimidin-2-yl)-2-[(5-methoxy-1H-indol-3-yl)methyl]-2,9-diazaspiro[5.5]undecan-1-one family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00325911 Functional Category Bioactive with Natural Product
Superfamily P2X purinoceptor 3 and Cytochrome P450 3A4 Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
Indeglitazar family 3 39
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Scavenger receptor class B member 1 ligand methyl 9-[3-(4,6-di... 2 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 2-[4-... 1 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 1 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 0
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 3
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(... 3 0
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
Serine/threonine-protein kinase ATR inhibitor 4-[2-(6-methoxy-... 1 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 1
Multidrug resistance-associated protein 1 inhibitor SureCN6823... 1 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 2 1
Neuropeptide Y receptor type 5 ligand 7-methoxy-2-methyl-6-phe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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