CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13682
Family Name C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohexyl-2-oxo-5-phenylimidazolidin-1-yl]piperidin-1-yl]methyl]phenoxy]benzamide family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00423668 Functional Category Bioactive
Superfamily Disintegrin and C-C chemokine receptor type 5 Binder Superfamily
Class Class 3124

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Cytochrome P450 1A2 and Cytochrome P450 3A4 inhibitor 4-[4-[2-... 2 3
Pol polyprotein inhibitor MDL 74538 family 11 1
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423666 CHEMBL2435878 Bioactive 4-[4-[[4-[(5R)-3-cyclohexyl-2-oxo-5-phenylimidazolidin-1-yl]piperidin-1-yl]methyl]phenoxy]-N-methylbenzamide
CFAMM00423665 CHEMBL2435879 Bioactive 4-[4-[[4-[(5R)-3-cyclohexyl-2-oxo-5-phenylimidazolidin-1-yl]piperidin-1-yl]methyl]phenoxy]-N,N-dimethylbenzamide
CFAMM00423669 CHEMBL2435881 Bioactive 4-[4-[[4-[(5R)-3-cyclohexyl-2-oxo-5-phenylimidazolidin-1-yl]piperidin-1-yl]methyl]phenoxy]benzoic acid
CFAMM00423668 CHEMBL2435880 Bioactive 4-[4-[[4-[(5R)-3-cyclohexyl-2-oxo-5-phenylimidazolidin-1-yl]piperidin-1-yl]methyl]phenoxy]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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