CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13683
Family Name C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(3-methylphenyl)-2-oxoimidazolidin-1-yl]piperidin-1-yl]butyl]-4,6-dimethylpyrimidine-5-carboxamide family
No. of Seeds 5 No. of Other Members 4
Family Centroid CFAMM00423676 Functional Category Bioactive
Superfamily C-C chemokine receptor type 5 Ligand Vicriviroc Superfamily
Class Class 824

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
C-C chemokine receptor type 5 Ligand Vicriviroc Family 4 31
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
RAC-gamma serine/threonine-protein kinase Inhibitor GDC-0068 F... 20 29
GDC-0349 family 44 77
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
C-C chemokine receptor type 5 ligand [3-[2-[(3aS,6aR)-5-(4,6-d... 3 40
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
C-C chemokine receptor type 5 ligand AC1NUXE1 family 12 7
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
C-C chemokine receptor type 5 ligand SureCN3684128 family 2 2
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Histamine H3 receptor ligand SureCN2878688 family 8 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Substance-P receptor ligand Netupitant family 5 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[acetyl(thio... 6 3
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 8 0
C-C chemokine receptor type 5 ligand 4-[[[[1-[(2R)-4-[(6-chlor... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-[2-(trif... 1 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cathepsin S and Cathepsin K inhibitor 2-cyano-N-[(2R)-1-phenyl... 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Collagenase 3 inhibitor MMP-13 Inhibitor family 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (3... 1 1
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
C-C chemokine receptor type 5 ligand AC1MHPAK family 5 1
C-C motif chemokine 5 inhibitor [(3aS,6aR)-2-[3-(1-cyclopentyl... 3 0
Beta-lactamase inhibitor CHEMBL1497312 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423673 CHEMBL2435897 Bioactive N-[3-[4-[3-cyclohexyl-5-(3,5-dimethylphenyl)-2-oxoimidazolidin-1-yl]piperidin-1-yl]butyl]-4,6-dimethylpyrimidine-5-carboxamide
CFAMM00423678 CHEMBL2435883 Bioactive N-[(3S)-3-[4-[(5R)-3-cyclohexyl-2-oxo-5-phenylimidazolidin-1-yl]piperidin-1-yl]butyl]-4,6-dimethylpyrimidine-5-carboxamide
CFAMM00423677 CHEMBL2435898 Bioactive N-[3-[4-[3-cyclohexyl-5-(3-fluoro-5-methylphenyl)-2-oxoimidazolidin-1-yl]piperidin-1-yl]butyl]-4,6-dimethylpyrimidine-5-carboxamide
CFAMM00423676 CHEMBL2435890 Bioactive N-[3-[4-[3-cyclohexyl-5-(3-methylphenyl)-2-oxoimidazolidin-1-yl]piperidin-1-yl]butyl]-4,6-dimethylpyrimidine-5-carboxamide
CFAMM00423675 CHEMBL2435892 Bioactive N-[3-[4-[5-(3-chlorophenyl)-3-cyclohexyl-2-oxoimidazolidin-1-yl]piperidin-1-yl]butyl]-4,6-dimethylpyrimidine-5-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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