CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM137
Family Name Bifunctional dihydrofolate reductase-thymidylate synthase and Dihydrofolate reductase inhibitor AC1NUILW family
No. of Seeds 6 No. of Other Members 11
Family Centroid CFAMM00244273 Functional Category Bioactive
Superfamily Dihydrofolate reductase and Bifunctional dihydrofolate reductase-thymidylate synthase Binder Superfamily
Class Class 824

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Folate receptor gamma Ligand Folic Acid Family 4 100
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
JAK Inhibitor Momelotinib Family 33 83
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 11
Thymidylate synthase inhibitor AC1LAB82 family 17 0
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Thymidylate synthase inhibitor AGN-PC-0757PM family 1 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
Growth hormone secretagogue receptor type 1 ligand SureCN62436... 8 6
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 1
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Dihydrofolate reductase inhibitor 5-[4-[(3,4-dichlorophenyl)me... 1 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-(2-aminoethyl)pipe... 17 2
P2Y purinoceptor 12 inhibitor (4S)-4-[[6-[4-[2-(methylamino)-2... 51 8
Dihydrofolate reductase type 1 and Dihydrofolate reductase inh... 1 0
Thymidylate synthase and Dihydrofolate reductase inhibitor (2S... 1 0
Histone deacetylase 1 inhibitor N-(2-aminophenyl)-4-[[[4-(cycl... 5 3
Histone deacetylase 1 inhibitor N-(2-aminophenyl)-4-[[(4,6-dim... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00307882 CHEMBL102967 Bioactive AC1NUILZ
CFAMM00307873 CHEMBL103086 Bioactive AGN-PC-00J5QJ
CFAMM00307880 CHEMBL102447 Bioactive AC1NUIM8

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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