CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13701
Family Name Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-4-fluoropiperidin-4-yl]-[4-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)piperidin-1-yl]methanone family
No. of Seeds 7 No. of Other Members 0
Family Centroid CFAMM00423734 Functional Category Bioactive
Superfamily Histamine H3 receptor and Peptide deformylase Binder Superfamily
Class Class 10

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Reverse transcriptase Inhibitor Nevirapine Family 23 640
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Amg 423 family 7 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Class II cytokine receptor Ligand IL-10 Family 7 45
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 2 26
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-quinolin... 6 8
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Reverse transcriptase/RNaseH inhibitor AC1MHDLR family 2 1
C-C chemokine receptor type 5 ligand AC1LA25C family 3 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Dipeptidyl peptidase 4 inhibitor SureCN3389584 family 2 2
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 1 0
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-isoquinolin-1-y... 3 2
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Transient receptor potential cation channel subfamily V member... 57 4
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 0
Calcitonin gene-related peptide type 1 receptor ligand (2R)-5-... 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 5
Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Transient receptor potential cation channel subfamily V member... 1 0
Transient receptor potential cation channel subfamily V member... 3 2
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Stromelysin-1 and Interstitial collagenase inhibitor 1-[(2S)-1... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423735 CHEMBL2436627 Bioactive [1-[(2-aminopyridin-4-yl)methyl]-4-fluoropiperidin-4-yl]-[4-(3,4-dihydro-1H-isoquinolin-2-yl)piperidin-1-yl]methanone
CFAMM00423734 CHEMBL2436622 Bioactive [1-[(2-aminopyridin-4-yl)methyl]-4-fluoropiperidin-4-yl]-[4-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)piperidin-1-yl]methanone
CFAMM00423733 CHEMBL2436628 Bioactive 2-[1-[1-[(2-aminopyridin-4-yl)methyl]-4-fluoropiperidine-4-carbonyl]piperidin-4-yl]-3,4-dihydro-1H-isoquinoline-7-carbonitrile
CFAMM00423732 CHEMBL2436629 Bioactive [1-[(2-aminopyridin-4-yl)methyl]-4-fluoropiperidin-4-yl]-[4-(1,3-dihydroisoindol-2-yl)piperidin-1-yl]methanone
CFAMM00423731 CHEMBL2436630 Bioactive [1-[(2-aminopyridin-4-yl)methyl]-4-fluoropiperidin-4-yl]-[4-(5-fluoro-1,3-dihydroisoindol-2-yl)piperidin-1-yl]methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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