CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13713
Family Name Mitogen-activated protein kinase kinase kinase 11 and Leucine-rich repeat serine/threonine-protein kinase 2 inhibitor 3-(1H-indol-5-yl)-5-(3,4,5-trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine family
No. of Seeds 1 No. of Other Members 2
Family Centroid CFAMM00423800 Functional Category Bioactive with Natural Product
Superfamily Adenosine kinase and Tubulin beta-4A chain Binder Superfamily
Class Class 1144

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 3
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Focal adhesion kinase 1 inhibitor AGN-PC-00AVK6 family 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 2 2
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
Dual specificity protein kinase CLK4 and Dual specificity prot... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 1 0
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1
C-X-C chemokine receptor type 3 ligand (6aR,9R)-9-N,9-N-diethy... 1 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423800 CHEMBL2436980 Bioactive 3-(1H-indol-5-yl)-5-(3,4,5-trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26400 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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