CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13716
Family Name Epidermal growth factor receptor ligand N-[3-[2-(4-morpholin-4-ylanilino)-7-oxopteridin-8-yl]phenyl]prop-2-enamide family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00423813 Functional Category Bioactive
Superfamily Cyclin-dependent kinase 4 Inhibitor PD-332991 Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Translocator protein Inhibitor Emapunil Family 7 89
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 1 4
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 11 2
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Receptor-type tyrosine-protein kinase FLT3 ligand 4-[6-amino-5... 1 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 5 0
Transient receptor potential cation channel subfamily V member... 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423814 CHEMBL2437462 Bioactive N-[3-[2-[4-(4-methylpiperazin-1-yl)anilino]-7-oxopteridin-8-yl]phenyl]prop-2-enamide
CFAMM00423813 CHEMBL2437460 Bioactive N-[3-[2-(4-morpholin-4-ylanilino)-7-oxopteridin-8-yl]phenyl]prop-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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