CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13717
Family Name Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyphenyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00423819 Functional Category Bioactive
Superfamily Dipeptidyl peptidase 4 Binder Superfamily 10
Class Class 323

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Oxytocin receptor Ligand Oxytocin Family 30 182
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Zucapsacin family 7 177
Thymopentin family 20 133
Plitidepsin family 15 5
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 1 0
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 2 1
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(4-hydroxy-... 2 0
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Beta-lactamase inhibitor sodium;(1R,5S)-4-[2-amino-2-(4-hydrox... 1 0
Signal transducer and activator of transcription 3 inhibitor [... 7 25
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423819 CHEMBL243798 Bioactive (2S)-1-[(2S,4R)-4-(3-hydroxyphenyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00423818 CHEMBL390221 Bioactive (2S)-1-[(2S,4R)-4-(4-hydroxyphenyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00423817 CHEMBL389324 Bioactive (2S)-1-[(2S,4R)-4-(3-hydroxy-2,4,6-trimethylphenyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00423816 CHEMBL245059 Bioactive (2S)-1-[(2S,4R)-4-(2-hydroxyphenyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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