CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1372
Family Name Sodium-dependent dopamine transporter and Sigma non-opioid intracellular receptor 1 ligand 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-[(E)-3-(furan-2-yl)prop-2-enyl]piperazine family
No. of Seeds 7 No. of Other Members 5
Family Centroid CFAMM00265777 Functional Category Bioactive
Superfamily DNA-dependent protein kinase catalytic subunit Inhibitor 2-(benzofuran-2-yl)-6-morpholino-4h-pyran-4-one Superfamily
Class Class 769

Cousin Family NamesSeedsMembers
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Histamine H3 receptor Ligand A-317920 Family 9 240
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 4 18
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Fatty-acid amide hydrolase 1 Inhibitor Furan-2-ylmethylcarbami... 1 105
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 62
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 8 36
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 2
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 0
Lethal(3)malignant brain tumor-like protein 1 and Lysine-speci... 1 6
Histamine H3 receptor ligand SureCN2786002 family 8 3
Histamine H3 receptor ligand SureCN2785131 family 7 1
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 2 4
Lysosomal Pro-X carboxypeptidase inhibitor 1'-(1-benzofuran-2-... 1 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Protein kinase C theta type and Protein kinase C epsilon type ... 1 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 5 3


External ID

Functional Category

Molecule Name

CFAMM00322610 CHEMBL1202018 Bioactive 3-[2-[bis(4-fluorophenyl)methoxy]ethyl]-8-[(E)-3-(furan-2-yl)prop-2-enyl]-3,8-diazabicyclo[3.2.1]octane;oxalic acid
CFAMM00322609 CHEMBL163273 Bioactive AGN-PC-00GBOB
CFAMM00322615 CHEMBL1161987 Bioactive 3-[2-[bis(4-fluorophenyl)methoxy]ethyl]-6-[(E)-3-(furan-2-yl)prop-2-enyl]-3,6-diazabicyclo[3.1.1]heptane;(E)-but-2-enedioic acid
CFAMM00322611 CHEMBL346591 Bioactive 1-(2-benzhydryloxyethyl)-4-[(E)-3-(furan-2-yl)prop-2-enyl]piperazine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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