CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13724
Family Name Vascular endothelial growth factor receptor 2 and Angiopoietin-1 receptor ligand imidazopyridine-urea, 44 family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00169143 Functional Category Bioactive
Superfamily Vascular endothelial growth factor receptor 2 and Tyrosine-protein kinase Lyn Binder Superfamily
Class Class 3054

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Histamine H1 receptor Ligand Astemizole Family 7 240
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Cyclin-dependent kinase 2 Inhibitor 6-cyclohexylmethyloxy-2-(4... 2 11
Methylated-DNA--protein-cysteine methyltransferase Inhibitor 6... 4 5
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Neuropeptide Y receptor type 5 and Alpha-1A adrenergic recepto... 8 2
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Translocator protein inhibitor SureCN6906757 family 3 2
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 4
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 1 0
Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Sterol O-acyltransferase 1 inhibitor 1-[4-[2-(4,5-diphenyl-1H-... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Glucagon receptor ligand SureCN2647807 family 3 7
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJ2 family 1 0
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423852 CHEMBL244101 Bioactive imidazopyridine-urea, 43
CFAMM00423856 CHEMBL243915 Bioactive imidazopyridine-urea,42

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26843 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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