CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13730
Family Name Potassium voltage-gated channel subfamily KQT member 2 ligand (E)-3-(2,5-difluorophenyl)-N-[(1S)-1-(3-pyridin-4-yloxyphenyl)ethyl]prop-2-enamide family
No. of Seeds 3 No. of Other Members 4
Family Centroid CFAMM00423884 Functional Category Bioactive
Superfamily Bifunctional epoxide hydrolase 2 and Transient receptor potential cation channel subfamily V member 1 Binder Superfamily
Class Class 2472

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Smoothened homolog Inhibitor LDE225 Family 3 76
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Chymase Inhibitor NK3201 Family 1 0
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 3 24
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Renin Inhibitor CP-305202 Family 9 30
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
cAMP-dependent protein kinase type II-alpha regulatory subunit... 2 4
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(2-methoxy-3-methylpy... 2 3
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Prothrombin inhibitor AGN-PC-073H0Z family 9 6
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 14
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(4S)... 34 23
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)... 3 5
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 3 7
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Motilin receptor ligand SureCN2768193 family 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Transient receptor potential cation channel subfamily V member... 6 1
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-040NYD family 3 7
Renin inhibitor SureCN6042213 family 2 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Renin inhibitor SureCN7300793 family 2 5
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 4
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Lysophosphatidic acid receptor 1 and Lysophosphatidic acid rec... 3 6
Metabotropic glutamate receptor 2 ligand 1-butyl-4-[3-chloro-4... 4 14
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-0A9UZU fa... 3 0
Platelet-activating factor receptor ligand AGN-PC-001U4L family 2 0
Pol polyprotein inhibitor tert-butyl N-[(2S,3R)-3-hydroxy-4-[[... 1 1
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423885 CHEMBL401942 Bioactive (E)-3-(2-fluorophenyl)-N-[(1S)-1-(3-pyridin-3-yloxyphenyl)ethyl]prop-2-enamide
CFAMM00423884 CHEMBL2440363 Bioactive (E)-3-(2,5-difluorophenyl)-N-[(1S)-1-(3-pyridin-4-yloxyphenyl)ethyl]prop-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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