CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13734
Family Name Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 ligand 3-chloro-5-(5-fluoropyridin-3-yl)oxy-N-(6-methylpyridin-2-yl)benzamide family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00276450 Functional Category Bioactive
Superfamily Fatty-acid amide hydrolase 1 and Cytochrome P450 3A4 Binder Superfamily
Class Class 6

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Smoothened homolog Inhibitor LDE225 Family 3 76
MK-6096 family 3 69
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Coagulation factor X and Neutrophil elastase Inhibitor ZK-8140... 51 17
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 14 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Metabotropic glutamate receptor 5 ligand AGN-PC-0DB8TJ family 2 0
Orexin receptor type 1 and Orexin receptor type 2 ligand (1R,2... 6 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Coagulation factor X inhibitor 5-chloro-N-(5-chloropyridin-2-y... 1 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Metabotropic glutamate receptor 5 ligand AGN-PC-09QJ1Q family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00423912 CHEMBL2440640 Bioactive 3-chloro-5-(5-cyanopyridin-3-yl)oxy-N-(6-methylpyridin-2-yl)benzamide
CFAMM00423910 CHEMBL2440624 Bioactive SureCN6918115

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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